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The Rise of the Microbiome: The Relatively Short Road From Hunch to Hype to Hope The speed of discovery in revealing the hidden world in our gut has been staggering.…

Pregabalin may lessen pain from irritable bowel syndrome, study finds Patients suffering from pain related to irritable bowel syndrome (IBS) may benefit from taking pregabalin, a neuro-pain inhibitor commonly used…

Postexertion 'Crash,' not Fatigue per se, Marks Syndrome New research demonstrates numerous biological abnormalities accompanying and after even minimal exertion among patients with chronic fatigue syndrome, also… medscape.com Metabolic features…

A Neural Signature in Fibromyalgia Fibromyalgia is a well characterized condition with disordered pain processing. Although the clinical constellation and diagnostic clues are well characterized, FM… rheumnow.com New fibromyalgia recommendations…

Epigenetics & Inheritance We used to think that a new embryo's epigenome was completely erased and rebuilt from scratch. But this isn't completely true. Some epigenetic tags remain in place…

Shaping Variation in the Human Immune System http://www.cell.com/cms/attachment/2070962190/2068075869/mmc7.mp4 Immune responses demonstrate a high level of intra-species variation, compensating for the specialization capacity of pathogens. The recent advent of in-depth immune…

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity As part of the IHEC consortium, Arts et al. dissect how metabolic pathways regulate epigenetic rewiring in trained immunity…

Epigenetics: The keeper of the code The code stored in our DNA is no longer the whole story. The field of epigenetics is teaching us that the packaging is just…

Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells Tumor-infiltrating regulatory T cells can suppress effector T cells specific for tumor antigens. De Simone et al. (2016) demonstrate that…

Long-Term Outcomes of Aromatase Inhibitor Arthralgias Up to half of women on AI therapy experience joint pain, and up to 20% become non-compliant with their AI therapy because of joint…