The 9 Muses are daughters of Zeus and Mnemosyne, Greek goddesses personifying the inspiration for the sciences and the arts.
My highly opinionated news-blog draws inspiration from both the science and the art of Rheumatology.
A Neural Signature in Fibromyalgia Fibromyalgia is a well characterized condition with disordered pain processing. Although the clinical constellation and diagnostic clues are well characterized, FM… rheumnow.com New fibromyalgia recommendations…
Epigenetics & Inheritance We used to think that a new embryo's epigenome was completely erased and rebuilt from scratch. But this isn't completely true. Some epigenetic tags remain in place…
Shaping Variation in the Human Immune System http://www.cell.com/cms/attachment/2070962190/2068075869/mmc7.mp4 Immune responses demonstrate a high level of intra-species variation, compensating for the specialization capacity of pathogens. The recent advent of in-depth immune…
Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity As part of the IHEC consortium, Arts et al. dissect how metabolic pathways regulate epigenetic rewiring in trained immunity…
Epigenetics: The keeper of the code The code stored in our DNA is no longer the whole story. The field of epigenetics is teaching us that the packaging is just…
Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells Tumor-infiltrating regulatory T cells can suppress effector T cells specific for tumor antigens. De Simone et al. (2016) demonstrate that…
Long-Term Outcomes of Aromatase Inhibitor Arthralgias Up to half of women on AI therapy experience joint pain, and up to 20% become non-compliant with their AI therapy because of joint…
Juno, Kite Pharma: cancer cell therapies could be approved next year A new wave of experimental cancer drugs that directly recruit the immune system's powerful T cells could begin reaching…
Dendritic Cell Therapy for Cancer What is DC Therapy? Dendritic Cell (DC) Therapy or so-called Dendritic Cell vaccine is a newly emerging and potent form of immune therapy used to…
DNA Methylation Inhibitors in Cancer Therapy: The Immunity Dimension DNA demethylating agents are approved for some blood malignancies and are under active… cell.com Inhibiting DNA Methylation Causes an Interferon Response…
