Epigenetics & Immunity

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

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As part of the IHEC consortium, Arts et al. dissect how metabolic pathways regulate epigenetic rewiring in trained immunity (innate immune memory). They show that glycolysis, glutaminolysis, and cholesterol metabolism are indispensable in trained monocytes and link fumarate accumulation to epigeneti…

β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance

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As part of the International Human Epigenome Consortium (IHEC), this study reveals that β-glucan…