DNA demethylating agents are approved for some blood malignancies and are under active…
cell.com
DNA methyltransferase inhibitors upregulate endogenous retroviruses in tumor cells to induce an growth-inhibiting immune response. High expression of the genes associated with the anti-viral response seems to potentiate a response to immune checkpoint therapy.
cell.com
Combining epigenetic therapy and…
blog.aacr.org
Epigenetic regulation allows heritably modulating gene expression profiles without modifying the primary sequence of gDNA. Under physiologic conditions, epigenetic patterns determine tissue-specific gene expression landscapes, gene imprinting, inactivation of chromosome X, and preservation of genomi…
clincancerres.aacrjournals.org
A ground-breaking gene-editing technique is to be tested on humans for the first time, with Chinese oncologists trialling the innovation on lung cancer patients.
telegraph.co.uk
The move by Chinese scientists could spark a biomedical duel between China and the United States.
nature.com