Xanthine Oxidase

Regulation of uric acid metabolism and excretion


Purines perform many important functions in the cell, being the formation of the monomeric precursors of nucleic acids DNA and RNA the most relevant one. Purines which also contribute to modulate energy…


Therapeutic Effects of Xanthine Oxidase Inhibitors: Renaissance Half a Century after the Discovery of Allopurinol

The prototypical xanthine oxidase (XO) inhibitor…


Xanthine Oxidase, in generating reactive oxygen species (ROS), may well be the direct cause of many morbidities associated with hyperuricaemia.


Xanthinuria is a descriptive term for excess urinary excretion of the purine base xanthine. Two inherited forms of xanthinuria principally result from a deficiency of the enzyme xanthine dehydrogenase, which is the…


Can excessive and prolonged inhibition of xanthine oxidase result in acquired xanthinuria? Is xanthinuria the cause of the renal deterioration seen in patients with very low serum urate?