Uric Acid & Fatty Liver

More bad news for fructose? Read how fructose metabolism may contribute to metabolic syndrome and fat accumulation.
A little-known association with NAFLD is Hyperuricaemia and Gout. It is part of the Metabolic Syndrome involving Diabetes Mellitus, Hypertension, Dyslipidaemia and Obesity, so it’s difficult to tease its individual impact on cardiovascular and liver cirrhosis risks apart from the other risk factors.
However, a direct toxic and pro-inflammatory mechanism of uric acid on tissues (eg kidneys, joints, connective tissue) is known, so a causal relationship is plausible, perhaps even being the lynchpin between the Metabolic Syndrome and NAFLD.
We should seriously be treating Hyperuricaemia and Gout to crystal-dissolution target as proposed by the ACR/EULAR, and not just a pain-relief target as myopically suggested by the ACP.

The relationship of serum uric acid with non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) is a clinicopathological entity which is characterized…


High Serum Uric Acid Increases the Risk for Nonalcoholic Fatty Liver Disease: A Prospective Observational Study

Nonalcoholic fatty liver disease (NAFLD) is a…

Uric Acid Induces Hepatic Steatosis by Generation of Mitochondrial Oxidative Stress


Background: Uric acid is an independent risk factor in fructose-induced fatty liver, but whether it is a marker or a cause remains unknown.