TAFRO Syndrome & Castleman Disease

Proposed diagnostic criteria, disease severity classification and treatment strategy for TAFRO syndrome, 2015 version

TAFRO syndrome is a systemic inflammatory…

2015 diagnostic criteria for TAFRO (Thrombocytopenia-anasarca-fever-renal insufficiency-organomegaly) syndrome

Castleman Disease

Castleman disease (CD) is a rare disease of lymph nodes and related tissues. It is a heterogenous group of lymphoproliferative disorders that are sometimes associated with human immunodeficiency virus (HIV) and human herpesvirus 8 (HHV-8).

TAFRO syndrome or Castleman-Kojima syndrome: a variant of multicentric Castleman disease


![Figure][1]</img> A 14-year-old white young man was transferred from an outside hospital with a 4-week history of fever, 30-lb weight gain, and diarrhea. He was noted to have anasarca, elevated C-reactive protein (CRP), elevated creatinine, anemia, and thrombocytopenia. A detailed clinical work-up

Successful treatment of a Caucasian case of multifocal Castleman’s disease with TAFRO syndrome with a pathophysiology targeted therapy

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Castleman-Kojima disease (TAFRO Syndrome) is characterized by Thrombocytopenia, Anasarca, myeloFibrosis, Renal dysfunction, Organomegaly, multiple lymphadenopathy and histopathology pattern of atypical Castleman’s disease (CD). Only few cases …