T Lymphocyte

Innate Lymphocytes: Protector or Foe?

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Innate lymphocytes may have a role as disease targets in rheumatoid arthritis, psoriatic arthritis and/or inflammatory bowel disease, researchers say.

Where Innate Immunity and Autoimmune Disease Intersect

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In this article, we discuss the possibility of innate lymphocytes as therapeutic targets in rheumatic…

IL-33 in T Cell Differentiation, Function, and Immune Homeostasis

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Recent studies have highlighted a role for the alarmin interleukin (IL)-33 in CD4+ and CD8+ T cell activation and function, and have also revealed important distinctions. The IL-33 receptor ST2 is constitutively and abundantly expressed on T-helper-2 (Th2) and GATA-3+ regulatory T cells in a GATA-3-…

CD8+ T cells in human autoimmune arthritis: the unusual suspects

CD8+ T-cell differentiation in autoimmune inflammation.

Nature Reviews Rheumatology | Review Print…

↵2 Current address: Department of Neurology and Stroke, Hertie Institute for Clinical Brain Research, Eberhard Karls University, Tubingen, Germany.

Senescence of T Lymphocytes: Implications for Enhancing Human Immunity

As humans live longer, a central concern is to find ways to maintain their health as they age. Immunity declines during ageing, as shown by the increased susceptibility to infection by both previously encountered and new pathogens and by the decreased efficacy of vaccination. It is therefore crucial…