Septic Shock

Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study

The global burden of sepsis is estimated as 15 to 19 million cases annually, with a mortality rate approaching 60% in low-income countries.

The Magic Bullet in Sepsis or the Inflation of Chance Findings?

FINANCIAL/NONFINANCIAL DISCLOSURES: The authors have reported to CHEST the following: The Department of Intensive Care at Rigshosptialet (M. H. M. and A. P.) receives support for research from CSL Behring, Fresenius Kabi, and Ferring Pharmaceuticals. W. A. is Methodology Chair of Surviving Sepsis Ca…


We appreciate Dr Møller et al for their correspondence regarding our experience with the use of IV vitamin C, hydrocortisone, and thiamine in patients with severe sepsis/septic shock.1 First and foremost, it is important to state that we do not refute, nor did we attempt to mask, the characteristics…