RA: Pathogenesis

Understanding Role of Immunometabolism in RA

Increasing awareness of how metabolites regulate signaling pathways, guide post-translational…
mdedge.com

Do Fatty Acids Underlie Rheumatoid Arthritis Pathology?

According to a new study, patients with aggressive rheumatoid arthritis (RA) have lower levels of non-esterified fatty acids, which coincide with an enhanced Th1…
the-rheumatologist.org

Fatty acid metabolism in the regulation of T cell function

The specific regulation of cellular metabolic processes is of major importance for directing immune cell differentiation and function. We review recent evidence indicating that changes in basic cellular lipid metabolism have critical effects on T cell proliferation and cell fate decisions. While ind…
cell.com

C5a and Neutrophils as Early Mediators in Inflammatory Arthritis

Researchers from the Massachusetts General Hospital (MGH) have studied the initial steps in an animal model of inflammatory arthritis and found that complement C5a is critical to neutrophils migration into joints. The findings of these early events in the inflammatory cascade were published in Scien…
rheumnow.com

Novel Mechanisms for Rheumatoid Arthritis

The Journal of Leukocyte Biology has reported mechanisms whereby synovial CD4+ T cells producing IL-21 can contribute to the pathogenesis of RA by activating…
rheumnow.com

Peripheral Helper Cells May Provide Clue to RA Pathology

Research has identified a subset of T cells, peripheral helper (TPH) cells, which may promote pathological B cell responses and antibody production in…
the-rheumatologist.org

Novel Peripheral Helper T Cells in RA

Nature has published the findings from a group of US and UK researchers who have identified a unique subset of helper T-cells called ‘peripheral helper’…
rheumnow.com

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

CD4+ T cells are central mediators of autoimmune pathology; however, defining their key effector functions in specific autoimmune diseases remains challenging. Pathogenic CD4+ T cells within affected tissues may be identified by expression of markers of recent activation. Here we use mass cytometry…
nature.com