Osteoporosis: Anti-Resorptives

Denosumab Reduces Fracture Risks Better Than Alendronate in Real-World Users

By Chris Berrie…

Long-Term Use of Denosumab Safe in Postmenopausal Women With Osteoporosis

HOBOKEN, NJ — March 17, 2017 — A study published in Journal of Bone and Mineral…

As expected by the pharmacology of denosumab, this inhibition of remodeling is completely reversible upon stopping treatment

Warning: stopping Prolia (Denosumab) may result in a spike in vertebral fracture risk in the near term. Starting Prolia is a 5-10 years commitment, and an exit strategy needs to be carefully planned and executed.


In a study examining case definition for atypical femoral fractures (AFF), where sensitivity and specificity of radiographic fracture characteristics were calculated, lateral cortex transverse fracture pattern was the most sensitive and specific characteristic and the most highly agreed upon by revi…
A major concern driving the notion of a drug holiday in Osteoporosis treatment is the rare possibility of serious side-effects with various therapies; and all such medicines have their fair share of such.
One overblown concern with bisphosphonate use is Atypical Femoral Fracture.