Off-Label Tofacitinib Use in Dermatology

Reversal of CD8 T-Cell–Mediated Mucocutaneous Graft-Versus-Host-Like Disease by the JAK Inhibitor Tofacitinib

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The utility of allogeneic hematopoietic stem cell transplantation is limited by graft-versus-hostdisease (GVHD), a significant cause of morbidity and mortality. Patients with GVHDexhibit cutaneous manifestations with histological features of interface dermatitisfollowed by scleroderma-like changes.…

Evaluation of Tofacitinib in Early Diffuse Cutaneous Systemic Sclerosis

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Clinical Trials – This study will evaluate tofacitinib treatment in subjects with diffuse cutaneous systemic scleroderma (dcSSc) in a placebo…