OA Pathology: Bone

Off-Label Bisphosphonate Use Effective for Edema in Bone Marrow Lesions

Common adverse events were headache, pain in the extremities, and fatigue.

IV zoledronic acid and vitamin D reduces volume of…

New evidence bisphosphonates may prevent OA

LAS VEGAS – A favorable signal is seen in the Osteoarthritis Initiative.

Bisphosphonates: a therapeutic option for knee osteoarthritis?

Nowadays, the disease is regarded as a whole joint disease that affects different structures in and around the joint capsule: the cartilage and also the synovial tissue, subchondral bone, muscles, ligaments and entheses are involved. In the absence of effective therapeutic options that modify the course of the disease, it is attractive to split up the options for interventions in different targets: cartilage, subchondral bone, synovitis and central pain regulation…

Improved clinical outcome measures of knee pain and function with concurrent resolution of subchondral Bone Marrow Edema Lesion and joint effusion in an osteoarthritic patient following Pentosan Polysulphate Sodium treatment: a case report

At present, there are no registered products for the treatment of subchondral Bone Marrow Edema Lesion (BML) and associated knee pain. Patients who do not respond to current anti-inflammatory therapies are left with limited treatment options, and may resort to operative management with Total Knee Ar…

Osteophytes: relevance and biology

Schematic representation of a murine knee joint

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Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes

Osteoarthritis (OA) is a major cause of disability in the…