OA Pathology: Bone

Nowadays, the disease is regarded as a whole joint disease that affects different structures in and around the joint capsule: the cartilage and also the synovial tissue, subchondral bone, muscles, ligaments and entheses are involved. In the absence of effective therapeutic options that modify the course of the disease, it is attractive to split up the options for interventions in different targets: cartilage, subchondral bone, synovitis and central pain regulation…