Selectively removing old or ‘senescent’ cells from joints could stop and even reverse the…
sciencedaily.com
Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
<p>Pharmacological or genetic depletion of senescent…
nature.com
Scientists Race to Regrow Lost Knee Cartilage
About 14 million Americans have osteoarthritis of the knees severe enough to cause pain and inflammation, according to the Arthritis Foundation, and more people are getting the condition — also known as OA — as they age.
medscape.com
The real DMOADs (Disease Modifying OsteoArthritis Drugs) are here:
1) MIV-711 (Cathepsin K inhibitor)
2) Sprifermin (Fibroblast Growth Factor 18)
3) Samumed (Wnt inhibitor)
The FDA has granted fast track designation to MIV-711.
rheumatologyadvisor.com
SAN DIEGO — The structural benefits of sprifermin, a novel recombinant human fibroblast growth factor 18, suggest it may be effective for the disease-modifying treatment of osteoarthritis, according to research…
healio.com
VIDEO: Intra-articular sprifermin prevented cartilage loss in patients with knee OA
healio.com
FGF-18 Drug Builds Knee Cartilage in Osteoarthritis
But two-year phase II data fail to show clinical symptom…
medpagetoday.com
Inhibition of the Wnt pathway with the small molecule…
rheumatologyadvisor.com
Samumed Successfully Completed 52-Week Phase 2 Study for Treatment of Osteoarthritis of the Knee
Samumed Successfully Completed 52-Week Phase 2 Study for Treatment of Osteoarthritis of the Knee