New PsA Treatments

Objective To assess the safety and efficacy of ixekizumab, a monoclonal antibody that inhibits interleukin-17A, in a double-blind phase III trial…

Enthesitis refers to the instance of inflammation at the point where a tendon joins to a bone. Looking for…|By Ryan Black

A20, a protein produced by macrophages, is a natural down-regulator of the pro-inflammatory STAT1 intracellular signal. Its deficiency in mice is associated with the development of enthesitis, a hallmark of Psoriatic Arthritis.
This discovery raises the possibility that a JAK-STAT inhibitor currently available for RA treatment, Tofacitinib, may prove effective for treating PsA.

A20 inhibition of STAT1 expression in myeloid cells: a novel endogenous regulatory mechanism preventing development of enthesitis

Objectives A20 is an important endogenous regulator of inflammation. Single nucleotide polymorphisms in A20 have been associated with various immune-mediated inflammatory diseases, and cell-specific deletion of A20 results in diverse inflammatory phenotypes. Our goal was to delineate the underlying…