Lupus or not lupus? Neuropsychiatric symptom attribution in systemic lupus erythematosus academic.oup.com Complement Driven Vasculopathy Underlies Neuropsychiatric Lupus Neuropsychiatric lupus (NPSLE) is a diagnostic challenge as its clinical manifestations are protean and the pathophysiology is poorly understood. rheumnow.com Complement Activation May Explain Brain Injury in NPSLE Findings support continuum of brain injury in lupus medpagetoday.com