Microbiome & SpA

Gut Microbiota Perturbations in Reactive Arthritis and Postinfectious Spondyloarthritis

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OBJECTIVE Reactive arthritis (ReA) is an inflammatory disorder occurring several weeks after gastrointestinal or genitourinary tract infections. HLA-B27 positivity is considered a risk factor, although it is not necessarily predictive of disease incidence. Among nongenetic factors, the intestinal mi…

Age and fecal microbial strain-specific differences in patients with spondyloarthritis

BACKGROUND Prior studies have demonstrated abnormalities in the composition of the gastrointestinal microbiota in pediatric and adult patients with spondyloarthritis (SpA). In particular, diminished fecal abundance of Faecalibacterium prausnitzii and abnormalities in both directions in the abundance…