Methotrexate in PsA

Does methotrexate improve synovitis in psoriatic arthritis?

Contrary to conventional wisdom and common practice of using MTX as first line treatment of PsA, a gold standard clinical trial showed no statistically significant benefit when joint outcomes were objectively measured. Skin scores, and patients’ and doctors’ overall assessments, though, were positive.

J Rheumatol. 2016 Jul 15. pii: jrheum.160111. [Epub ahead of print]|By Sheane BJ , et al.

Less than 20% of patients with Psoriatic Arthritis achieve remission in all domains on Methotrexate alone.

Analysis supports daily folate for children with psoriasis on methotrexate