What does the latest clinical research tell us about the optimal use of this powerful drug?

How does MTX really work in controlling rheumatic diseases? We’re still discovering novel modes of action.

Objectives Methotrexate (MTX) functions as an antiproliferative agent in cancer and an anti-inflammatory drug in rheumatoid arthritis (RA). Although macrophages critically contribute to RA pathology, their response to MTX remains unknown. As a means to identify MTX response markers, we have explored…

MTX may be more targeted in immunomodulation than we think.