Does Folic Acid Reduce the Toxicity of Methotrexate?

When used to treat rheumatoid arthritis, low-dose methotrexate may cause adverse effects related to folate antagonism and/or folate deficiency.

Folate supplementation and methotrexate treatment in RA: a review

Objectives. The folate antagonist methotrexate (MTX) has become established as the most commonly used disease-modifying anti-rheumatic drug (DMARD) in the treatment of rheumatoid arthritis (RA) but is commonly discontinued due to adverse effects. Adverse effects are thought to be mediated via folate…

Folic Acid with Methotrexate: the Debate

Folic acid & methotrexate: a tug of war Methotrexate is the most common medicine used to treat Rheumatoid Arthritis. However, some say it is still a mystery exactly how it works. Several sources I’ve read say that, because methotrexate is a folate…