Lupus Nephritis

Lupus Nephritis

Advanced sclerosis lupus nephritis. International

Lupus nephritis, one of the most serious manifestations of systemic lupus erythematosus (SLE), usually arises within 5 years of diagnosis; however, renal failure rarely occurs before American College of…

Pathophysiology and Treatment of Human Lupus Nephritis

Gain a better understanding of the pathophysiology of lupus nephritis and learn about the best therapeutic strategies for this disease.

Update on Lupus Nephritis

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SLE is a chronic inflammatory disease that affects the kidneys in about 50% of patients. Lupus nephritis is a major risk factor for overall morbidity and mortality in SLE, and despite potent anti-inflammatory and immunosuppressive therapies still ends in CKD or ESRD for too many patients. This revie…

Liquid Biopsy Provides Insights into Lupus

Microparticles in the blood of SLE patients may be a source of extracellular HMGB1, which is involved in immune response. Researchers found that analysis may be…
Management of lupus nephritis (LN) would be greatly aided by the discovery of biomarkers that accurately reflect changes in disease activity. Here, we used a proteomics approach to identify potential urinary biomarkers associated with LN. Urine was obtained from 60 LN patients with paired renal biop…

Urinary Biomarker Index Measures LN Activity Without Biopsy

The index accuracy appears to be minimally influenced by LN chronicity and concurrent use of medications, including those targeting the renin-angiotensin-aldosterone system
The Renal Activity Index for Lupus (RAIL) was developed utilizing urinary biomarkers of LN to avoid kidney biopsy.

MicroRNAs linked to treatment response in lupus nephritis

MELBOURNE – Expression of six microRNAs in kidney biopsy samples helped to predict response to cyclophosphamide.

Lupus nephritis expert offers management tips

Dr. Frédéric Houssiau of Cliniques Universitaires Saint-Luc in Brussels

MELBOURNE – Dr. Frédéric Houssiau gives advice on comorbidity management and induction therapy in lupus nephritis, among other things.

Lupus Nephritis Therapies Reviewed

Singh and colleagues have published a systematic review and Bayesian network metaanalyses of…

Treatments for Lupus Nephritis: A Systematic Review and Network Metaanalysis

Jasvinder A. Singh, Alomgir Hossain, Ahmed Kotb, Ana Oliveira, Amy S. Mudano, Jennifer Grossman, Kevin Winthrop and George A. Wells

Induction and Maintenance Immunosuppression Treatment of Proliferative Lupus Nephritis: A Network Meta-analysis of Randomized Trials

Rankings for efficacy and safety of immunosuppression treatment to induce ...

An induction regimen that includes a calcineurin inhibitor can help patients with acute lupus nephritis achieve complete or partial remission, early research suggests.

Aurina Announces Plans for Single Phase III Clinical Trial for Voclosporin

We are devoted to solving the mystery of lupus, one of the world’s cruelest, most unpredictable, and devastating diseases, while giving caring support to those who…

Review of Lupus Nephritis Supports Eculizumab as a Potential Treatment

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Read about a review study that supports eculizumab (Soliris) as a potential new treatment for SLE patients with renal involvement, called lupus nephritis.

JAK3-STAT pathway blocking benefits in experimental lupus nephritis

Lupus nephritis (LN) is a complex chronic autoimmune disease of unknown etiology characterized by loss of tolerance against several self-antigens. Cytokines are…