Leflunomide in Pregnancy

Leflunomide use during pregnancy and the risk of adverse pregnancy outcomes

Objectives Leflunomide is known to be embryotoxic and teratogenic in rodents. However, there is less evidence in humans. We quantified the risk of major…

Compared to other conventional DMARDs (deemed “safe” in pregnancy), biological DMARDs, corticosteroids and NSAIDs, Leflunomide did not increase the risk for major congenital malformations, miscarriages or low birth weight.  Although the adjusted odds ratio for prematurity was 4-fold, it was not statistically significant.