Osteoarthritis (OA) is a heterogeneous, multi-tissue disease. We hypothesised that different histopathological features characterise different stages during knee OA progression, and that discrete subgroups can be defined based on…
oarsijournal.com
We often think of OA as a homogenous degenerative disease entity, involving the wearing down of articular cartilage, and devoid of inflammation.
This is now seen to be untrue, in light of new discoveries. Of the 3 main tissue types involved (cartilage, bone, synovium), synovial inflammation is seen to be a major source of pain and a driver of disease progression.
Perhaps more refined clinical subtype characterisation can lead to more effective individualised treatment of OA.
To describe the natural history of patellofemoral (PF)…
onlinelibrary.wiley.com
Purpose To investigate the risk of radiographic joint space narrowing (JSN) progression evaluated in subjects with and those without underlying osteoarthritis at baseline and knee replacement (KR) associated with meniscal surgery in subjects with and those without a reported history of preceding kne…
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Controversy surrounds whether meniscal surgery may inadvertently lead to faster knee OA deterioration, resulting in joint replacement surgery eventually. It appears from this study that if meniscal surgery is done for traumatic meniscal injury, the answer is no. In contrast, meniscal surgery for degenerative tears may be ill-advised: joint cartilage subsequently deteriorated faster, with more requiring earlier knee replacement surgery.
A small, partial-thickness focal cartilage defect in the tibiofemoral joint compartment has the same impact…
mdedge.com
It appears that, like bone marrow oedema, OA progression in pre-existing cartilage damage is restricted to the same joint compartment and the immediate adjacent cartilage. There is no “spreading”.
To identify the independent relation of synovitis with incident radiographic knee osteoarthritis (OA) after adjusting for other structural factors known to cause…
oarsijournal.com
The greater the volume of synovitis, the higher the risk of OA knee. Is the relationship causal? If so, which caused which?
Synovial Fluid White Blood Cell Count in Knee Osteoarthritis: Association With Structural Findings and Treatment Response
Osteoarthritis (OA) is a disease with a significant inflammatory component. The aim of this analysis was to determine the relationship between synovial fluid (SF) white blood cell (WBC) count and 2 parameters:… onlinelibrary.wiley.com
OA synovial fluid white blood cell count level, while not in the realm of outright inflammatory arthritides like RA or Gout, correlates with synovial volume (inflammatory burden), as well as with the degree of pain relief with intra-articular steroid injection.
To identify the independent relation of synovitis with incident radiographic knee osteoarthritis (OA) after adjusting for other structural factors known… oarsijournal.com
Synovitis (evidenced by increased synovial volume and/or effusion), but not bone marrow oedema, correlates with increased pain sensitization, both locally (the knee) and elsewhere (generalised).