Intra-Articular Steroid in OA: Hit or Miss?

Steroid Injections for Knee Osteoarthritis May Promote Cartilage Loss

Treatment of knee osteoarthritis (with synovitis) with an injection of a corticosteroid every three months over two years resulted in significantly greater cartilage volume loss and no significant difference in knee pain compared to patients who received a placebo injection, according to a study pub…
rheumnow.com

Comparison of Intra-articular Triamcinolone vs Saline for Knee Osteoarthritis

This randomized trial compares the effects of intra-articular triamcinolone vs saline injected every 3 months for 2 years on changes in cartilage volume and pain in…
jamanetwork.com

Intra-articular corticosteroid injections seen as efficacious for short-term management of knee OA

According to a study in the Journal of the American Academy of Orthopaedic Surgeons, intra-articular…
healio.com

Intra-articular steroid worked better:
1) in the short term up to 3 months;
2) in those whose Xray showed less severe structural damage;
3) in the non-obese.

Structural predictors of response to intra-articular steroid injection in symptomatic knee osteoarthritis

The aim was to examine if structural factors…
arthritis-research.biomedcentral.com

Those with more severe structural damage on Xray or MRI responded less well to intra-articular steroid than those with less severe disease.

Flexion Therapeutics announced friday that the U.S. Food and Drug Administration (FDA) has approved its osteoarthritis (OA) of the knee injectable steroid drug Zilretta with the indication of moderate-to-severe knee pain.
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