Versatile functions for IL-6 in metabolism and cancer

large Image
Interleukin-6 (IL-6) in metabolism and cancer. IL-6 effects are highly context-dependent: beneficial effects have been reported in metabolism for many tissues including liver, skeletal muscle, white adipose tissue (WAT), brown adipose tissue…

IL-6 as a keystone cytokine in health and disease

Two distinct modes of IL-6 receptor signaling.

IL-6 control of B cells and humoral immunity.

Effect of IL-6 on T cell activities.

Therapeutic targeting of IL-6 and its receptor.

IL-6 has context-dependent pro- and anti-inflammatory properties and is now regarded as a prominent target for clinical intervention. Hunter and Jones discuss the effect of IL-6 on innate and adaptive immunity, and consider how the immunobiology of IL-6 may inform clinical decisions.

The IL-6 Wars 

large Image
In the years to come, the availability of numerous new IL-6 inhibitors it will either complicate treatment decisions, alter existing treatment paradigms, or result in an…

Tocilizumab raises cholesterol, but not cardiovascular events


Kevzara (Sarilumab) Approved in Canada for RA

Regeneron and Sanofi announced today that Health Canada has approved Kevzara (sarilumab), its interleukin-6 (IL-6) receptor monoclonal antibody, for…