Activation and signalling of IL-1.Main functions of IL-1.Strategies to achieve therapeutic inhibition of IL-1.
and IL-1β, two key cytokines in the activation of innate immunity. These cytokines were among the first proteins identified as orchestrators of leukocyte…

This is a key cytokine in driving not just the esoteric Autoinflammatory Syndromes like the familial periodic fevers, but the increasingly common innate inflammation causing Gout, Osteoarthritis, Osteoporosis, Atherosclerosis and Diabetes Mellitus.

 Large image of Figure 1.