![Activation and signalling of IL-1.](http://www.nature.com/nrrheum/journal/v12/n1/images/nrrheum.2016.166-f1.jpg)
![Main functions of IL-1.](http://www.nature.com/nrrheum/journal/v12/n1/images/nrrheum.2016.166-f2.jpg)
![Strategies to achieve therapeutic inhibition of IL-1.](http://www.nature.com/nrrheum/journal/v12/n1/images/nrrheum.2016.166-f3.jpg)
and IL-1β, two key cytokines in the activation of innate immunity. These cytokines were among the first proteins identified as orchestrators of leukocyte…
nature.com
This is a key cytokine in driving not just the esoteric Autoinflammatory Syndromes like the familial periodic fevers, but the increasingly common innate inflammation causing Gout, Osteoarthritis, Osteoporosis, Atherosclerosis and Diabetes Mellitus.
sciencedirect.com