Overview of IgG4-related disease
Immunoglobulin G4-related disease (IgG4-RD) is an increasingly recognized immune-mediated condition comprised of a collection of disorders that share particular pathologic, serologic, and clinical features. These disorders were previously thought to
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IgG4-related disease: a systematic review of this unrecognized disease in pediatrics
Immunoglobulin G4-related disease (IgG4-RD) is a systemic fibro-inflammatory condition with an unclear pathophysiological mechanism affecting different parts of…
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Primer: IgG4-Related Diseases
IgG4-related diseases first appeared in the medical literature in 2003, but greater awareness is needed to ensure early diagnosis.
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Circulating IgG4/IgG ASC percentages of greater than five percent are a more sensitive and reliable marker for disease activity in patients with IgG4-RD, researchers report.
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Short of tissue histology demonstrating IgG4-secreting plasma cells, serum IgG4 levels would help in diagnosis and monitoring.
History of malignancy more than three times as common than in controls
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Invasive cancers like prostate cancer, and those involving immune cells like lymphoma, are postulated to predispose to later development of IgG4-RD as a result of immune dysregulation reacting to neo/auto-antigens.
So far, the evidence does not suggest that IgG4-RD is pre-malignant, nor is it a paraneoplastic phenomenon.
IgG4-related disease: pathophysiologic insights drive emerging treatment approaches
Clin Exp Rheumatol. 2016 Jul-Aug;34(4 Suppl…