How Metformin Works

Metformin Mechanism

Metformin is a biguanide widely used for the therapy of type 2 diabetes mellitus. It has been shown that this compound ameliorates hyperglycemia without promoting insulin secretion, causing weight gain or generating hypoglycemia.…

Cellular and molecular mechanisms of metformin: an overview

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Considerable efforts have been made since the 1950s to better understand the cellular and molecular mechanisms of action of metformin, a potent…

Molecular mechanism of action of metformin: old or new insights?

Metformin is the first-line drug treatment for type 2 diabetes. Globally, over 100 million patients are…

Effects of metformin on the gut microbiome

The effects of metformin on the gut microbiome is stimulation of the beneficial gut bacterium, Akkermansia, which prevents a leaky gut and inflammation.

Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug

A randomized clinical trial reveals that the antidiabetic effects of metformin are at least partially due to beneficial changes in the microbiota.

Effect of Metformin on Metabolic Improvement and Gut Microbiota

Metformin is commonly used as the first line of medication for the treatment of metabolic syndromes, such as obesity and type 2 diabetes (T2D). Recently, metformin-induced changes in the gut microbiota have been reported; however, the relationship between metformin treatment and the gut microbiota r…

The mechanisms of action of metformin

Metformin is a widely-used drug that results in clear benefits in relation to glucose metabolism and…