How Corticosteroid Works

Mechanisms of glucocorticoid activity.
Effects of glucocorticoids on inflammation.
Glucocorticoids inhibit signalling through Toll-like receptors.
Glucocorticoids modulate T cell activity.
Glucocorticoid-induced sensitization of innate immunity.
Article preview View full access options Nature Reviews Immunology | Review Print…
The penultimate anchor drug in Rheumatology, corticosteroid is both panacea and bane.
Almost 70 years since its introduction, which won its discoverers the Nobel Prize in Physiology/Medicine, we still don’t fully understand how it works or how it causes the various metabolic side-effects.