Gout Treatments

For acute gout, corticosteroids look safer than NSAIDs

A meta-analysis of six randomized, controlled trials suggests equal efficacy, but patients taking corticosteroids had a lower frequency of indigestion, nausea, and vomiting and a higher frequency of rash.

Allopurinol dose escalation to achieve serum urate below 6 mg/dL: an open-label extension study

Objectives To determine the long-term safety and efficacy of allopurinol dose escalation (DE) to…

The Differences in the Mechanisms of Action Between Allopurinol and Febuxostat

Evidence-Based Medicine Consult

Lesinurad Plus Febuxostat Effective for Tophaceous Gout

When lesinurad 400mg was added to febuxostat, significantly more patients achieved target sUA by Month 6 (76.1%; P<0.0001) vs. febuxostat alone (46.8%);…

FDA Approves Duzallo for Hyperuricemia Associated With Uncontrolled Gout

The US FDA has approved a new fixed-dose and dual-mechanism treatment option for uncontrolled gout.

Pegloticase Infusion Reactions Largely Seen in Non-Responders

The introduction of intravenous pegloticase (PEG) in 2010 was felt by many to be a major advance in the treatment of patients with severe, refractory tophaceous gout.  But for some, concerns over infusion reactions and safety have limited its use.