Trade Names: Cataflam (immediate release), Voltaren (enteric coated)  Voltaren XR (extended release), Arthrotec (diclofenac + misoprostol)

Drug Class: NSAID

Tablets: 25-, 50-, 75 mg; diclofenac/misoprostol: 50 mg/200 mcg or 75 mg/200 mcg
Sustained-release tablet (XR): 100 mg

Dose: 100–200 mg/day in two to four divided doses (100 mg once daily of sustained release)

Clinical Pharmacology: Well absorbed after oral administration; hepatic metabolism and renal excretion of metabolites; half-life 2–3 hours.

Comments: Local application of topical diclofenac  (1% gel) may  offer benefit to some patients with lower GI and CV risk.

See NSAIDs for Indications, Mechanism of Action, Contraindications, Precautions, Monitoring, Pregnancy Risk, Adverse Effects, Interactions, and Patient Instructions.

Adapted from: RheumaKnowledgy