Diabetes Mellitus

Clinical Review of Antidiabetic Drugs: Implications for Type 2 Diabetes Mellitus Management

Type 2 diabetes mellitus (T2DM) is a global pandemic, as evident from the global cartographic picture of diabetes by the International Diabetes Federation (http://www.diabetesatlas.org/). Diabetes mellitus (DM) is a chronic, progressive, incompletely understood metabolic condition chiefly characteri…


Gliflozins’ heart failure protection in type 2 diabetes confirmed

WASHINGTON – Cardioprotection appears to be a class effect of SGLT-2 inhibitors.


CANVAS Proves CV Safety, Metabolic Value of Canagliflozin

British diabetes expert Clifford Bailey offers his take on the CANVAS data


It appears that the cardioprotective effect of the Gliflozins is a class effect, and so is the increased limb amputation risk.

The cardiovascular risk reduction is independent of the sugar control. The uricosuric effect may be a contributor to the cardioprotection.

Glycosuria resulting in hypoperfusion of limbs affected by peripheral vascular disease may contribute to increased limb amputation.