Clinical Review of Antidiabetic Drugs: Implications for Type 2 Diabetes Mellitus Management
Type 2 diabetes mellitus (T2DM) is a global pandemic, as evident from the global cartographic picture of diabetes by the International Diabetes Federation (http://www.diabetesatlas.org/). Diabetes mellitus (DM) is a chronic, progressive, incompletely understood metabolic condition chiefly characteri…
journal.frontiersin.org
Gliflozins’ heart failure protection in type 2 diabetes confirmed
WASHINGTON – Cardioprotection appears to be a class effect of SGLT-2 inhibitors.
mdedge.com
CANVAS Proves CV Safety, Metabolic Value of Canagliflozin
British diabetes expert Clifford Bailey offers his take on the CANVAS data
medscape.com
It appears that the cardioprotective effect of the Gliflozins is a class effect, and so is the increased limb amputation risk.
The cardiovascular risk reduction is independent of the sugar control. The uricosuric effect may be a contributor to the cardioprotection.
Glycosuria resulting in hypoperfusion of limbs affected by peripheral vascular disease may contribute to increased limb amputation.