Cholesterol Crystallopathies: Atherosclerosis

Cholesterol Crystals Suggest Looming Heart Attack

Cholesterol crystals that pierce the arterial plaque and intima trigger local and systemic inflammation that can lead to a myocardial infarction (MI), according to a new study.

The crystal-induced activation of NLRP3 inflammasomes in atherosclerosis

Atherosclerosis is an inflammatory disease, which is accompanied by the deposition of cholesterol-rich lipids and the infiltration of macrophages. Other…

Drug Aimed at Inflammation May Lower Risk of Heart Disease and Cancer

canakinumab mechanism of action
A milestone finding for researchers, the connection of inflammatory responses to such illnesses could open the door to new treatments.

Novartis’ CANTOS Heart Trial Results Could Lead To Drastic Drop In Arthritis Drug Price

But who would have thought at the results of a heart disease study could potentially provide an unexpected financial benefit to those patients with juvenile arthritis.

Laboratory Investigation is the official journal of the United States and Canadian Academy of Pathology. Laboratory Investigation is available as both in print and online journal and is dedicated to the publication of original research that significantly advances the understanding of human and exper…

N-acetylcysteine may abrogate NLRP3 inflammasome activation. That’s a much cheaper option than Canakinumab, and infinitely safer where infection is concerned.