Autoinflammatory Syndromes

Periodic Fevers – autoinflammatory conditions

Support, resources for anyone affected by rare autoinflammatory disease; science, articles, patient stories, expert opinion, centre of excellence locator

Epigenetic Changes to Inflammasome Found in Autoinflammatory Syndromes

Autoinflammatory syndromes manifest as periodic fevers in children, and are the result of monogenic, “gain in function” gene alterations affecting the inflammasome.  The innate immune response is driven by inflammasomes, which are cytosolic multiprotein complexes in macrophages that respond to stimu…