AS Predispositions

Position 97 of HLA-B, a residue implicated in pathogenesis of ankylosing spondylitis, plays a key role in cell surface free heavy chain expression

Objective Association of position 97 (P97) residue polymorphisms in human leucocyte antigen (HLA)-B, including HLA-B*27, with ankylosing spondylitis (AS) has recently been reported. We studied the effect of P97 variations on cell surface expression of the AS-associated HLA-B*27 and HLA-B*51, and the…

Sexual Dimorphism Found in Immunologic Profiles of Patients with Ankylosing Spondylosis

A study that found distinct sexual dimorphism in the…|By Kathy Holliman

Unique Gut Microbiome Triggers AS, Research Hints

The differences in gut bacteria between carriers of the spondyloarthritis-linked HLA-B27 gene and noncarriers suggest a possible causative role in ankylosing spondylitis (AS), investigators report.