Tuberculosis & IFN-γ

Mendelian susceptibility to mycobacterial disease: genetic, immunological, and clinical features of inborn errors of IFN-γ immunity

Mendelian susceptibility to mycobacterial disease (MSMD) is a rare condition characterized by predisposition to clinical disease caused by weakly virulent mycobacteria, such as BCG vaccines and environmental mycobacteria, in otherwise healthy individuals …
ncbi.nlm.nih.gov

Mendelian susceptibility to mycobacterial diseases: Specific defects

Mendelian susceptibility to mycobacterial diseases (MSMD, MIM #209950) is caused by genetic defects in the mononuclear phagocyte/T helper cell type 1 (Th1) pathway. Patients with MSMD have increased susceptibility to systemic infections with weakly v
uptodate.com

Identification of a major epitope by anti-interferon-[gamma] autoantibodies in patients with mycobacterial disease

Cheng-Lung Ku and colleagues report that anti-interferon (IFN)-[gamma] autoantibodies in patients with disseminated mycobacterial infections recognize the C-terminus of IFN-[gamma], and suggest that autoantibodies may arise by molecular mimicry. The authors propose a therapeutic strategy to treat pa…
nature.com

People with acquired interferon-gamma deficiency/dysfunction can manifest with disseminated mycobacterial infections, including Tuberculosis. Even with appropriate anti-tuberculous antibiotics, they may not be able to clear the infection.

Acquired predisposition to mycobacterial disease due to autoantibodies to IFN-γ

1Department of Paediatrics and Wellcome Centre for Clinical Tropical Medicine, Imperial College London, London, United Kingdom. 2Department of Infection and Tropical Medicine, Northwick Park Hospital, Middlesex, United Kingdom. 3Groote Schuur Hospital and Red Cross Children’s Hospital, University of…
jci.org

Paradox of autoantibodies and immune deficiency: Interferon gamma antibodies and susceptibility to intracellular pathogens

Indian J Med Microbiol,Official peer-reviewed publication of Indian Association of Medical Microbiologists
ijmm.org

Rituximab as Successful Adjunct Treatment in a Patient With Disseminated Nontuberculous Mycobacterial Infection Due to Acquired Anti–Interferon-γ Autoantibody

An acquired immune deficiency due to interferon gamma (IFN-γ) autoantibodies was diagnosed in a 78-year-old Japanese man with treatment-refractory disseminated nontuberculous mycobacterial infection. In addition to standard antimycobacterial therapy, …
ncbi.nlm.nih.gov