Secukinumab for rheumatology: development and its potential place in therapy
Secukinumab for rheumatology: development and its potential place in therapy Marije I Koenders, Wim B…
dovepress.com|By Dove Press
The Th17 pathway is somewhat of a Jekyll & Hyde thing, playing either a protective/reparative role or a destructive/pathological role. Its main protective role is against fungus.
IL6 and TGF-beta drive a housekeeping differentiation, while IL21, IL23 and IL1-beta induce a pro-inflammatory differentiation. IFN-gamma (Th1) and IL4 (Th2) inhibit Th17 differentiation altogether.
The main Th17 effector cytokines are IL17A, IL17F, IL21 and IL22. The latter in turn characterises a whole distinct subset of T-helper population called Th22. But that’s another story for another day.
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