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Novel Biomarkers For Predicting Knee OA Progression
Researchers have found several biomarkers that hold promise as predictors of pain and structural worsening of knee osteoarthritis (OA). “A cure for osteoa
rheumatologyadvisor.com
Predicting OA progression: results from the Vancouver knee osteoarthritis progression study
| Variables | Adjusted Hazard ratio (95% CI) |
|---|---|
| History of mild injury | 14.06 (3.71, 53.32) |
| History of severe injury | 0.47 (0.06, 3.43) |
| KL grade 1 | 19.50 (2.57, 148.23) |
| KL grade 2 | 47.68 (4.96, 457.91) |
| KL grade 3 | 147.46 (12.82, 1696.7) |
| KL grade 4 | 4.75 (0.50, 44.76) |
| Quadriceps weakness | 14.32 (3.21, 63.84) |
| PF grind test | 0.11 (0.01, 0.86) |
| Patellar pain | 0.27 (0.08, 0.90) |
| Lateral TF tenderness | 0.15 (0.03, 0.72) |
| Abnormal gait | 4.28 (0.90, 20.23) |
| Fine crepitus | 0.77 (0.21, 2.91) |
| Coarse crepitus | 0.11 (0.01, 0.85) |
| Symptomatic hand OA | 0.24 (0.07, 0.81) |
To predict the progression of osteoarthritis (OA) in a population based cohort defined by MRI as the gold standard using clinical and radiographic variables.
oarsijournal.com
Prediction of progression of radiographic knee osteoarthritis using tibial trabecular bone texture
To develop a system for predicting the progression of radiographic knee osteoarthritis (OA) using tibial…
onlinelibrary.wiley.com
Knee tissue lesions and prediction of incident knee osteoarthritis over 7 years in a cohort of persons at higher risk
Among high risk individuals, whether knee lesions in…
oarsijournal.com
If MRI done early at symptom onset can reliably predict development of OA years down the line, shouldn’t we be doing more knee MRI, and earlier on?
If the early pathologies thus detected can be staunched or even reverted with targeted therapies, shouldn’t we be front-loading such treatments at a time when they can still make a difference to the course of the disease?
Is this the “window of opportunity” in OA?