Polymyositis Polymyositis is an idiopathic inflammatory myopathy that causes symmetrical, proximal muscle weakness; elevated skeletal muscle enzyme levels; and… emedicine.medscape.com Patients with Systemic Sclerosis/polymyositis Overlap Have a Worse Survival Rate Than Patients Without It m.jrheum.org HMGB1 as a Biomarker for Polymyositis and Dermatomyositis High mobility group box chromosomal protein 1 (HMGB1) is a DNA-binding protein that functions as a structural co-factor. HMGB1 is actively secreted by macrophage/monocytes via inflammatory stimuli and is elaborated during apoptosis. rheumnow.com