Calprotectin vs Acute-Phase Reactants to Discriminate RA, PsA Activity
Calprotectin (S100A8/A9) has the strongest association with ultrasound-detected synovitis and predicts response to biologic treatment: results from a longitudinal study of patients with established rheumatoid arthritis
Serum calprotectin level discriminated between clinical remission and low disease activity better than other acute phase reactants like ESR and CRP, correlating with composite disease activity measures and ultrasound grey scale and power Doppler gradings.
Long noncoding RNA expression profile in fibroblast-like synoviocytes from patients with rheumatoid arthritis
Requiring synovial biopsy, flow cytometry to isolate the fibroblast-like synoviocytes, and doing quantitative PCR to measure the long non–coding RNA expression, this test is so not making it to clinical practice anytime soon.
“…amelioration of pain and improvement of personal subjective feeling set in soon after the start of TNF neutralization, long before inflammation decline becomes identifiable using common clinical tests.”
Association of brain functional magnetic resonance activity with response to tumor necrosis factor inhibition in rheumatoid arthritis
“…brain activity decreased within 3 days after TNFi exposure in the responders, preceding clinical responses (day 7) and responses observed on the anatomic hand MRI (day 28).”