Knee OA ℞: DMOADs

Efficacy of Colchicine for the Reduction of Symptoms in Knee Osteoarthritis

Researchers sought to investigate the effectiveness of colchicine on pain and function in symptomatic knee osteoarthritis.
rheumatologyadvisor.com

So Colchicine did not relief knee OA pain, but it did reduce some proinflammatory cytokines. Perhaps if the study subjects were stratified, and those with an inflammatory phenotype were selected, the outcome might have been a positive one.

SM04690 (Wnt Inhibitor) Is a Potential Disease Modifying Drug in Patients With Moderate to Severe Symptomatic Knee Osteoarthritis

By Chris Berrie…
dgnews.docguide.com

MIV-711 (Cathepsin K Inhibitor) Reduces Bone, Cartilage Disease Progression in Patients With Knee Osteoarthritis

By Chris Berrie…
dgnews.docguide.com

Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair

ard.bmj.com

‘Bright future’ for growth factor therapy in osteoarthritis

LIVERPOOL, ENGLAND – Growth factors under development for OA aim to treat the growing population of patients with OA at a younger age.
mdedge.com