Glucosamine and Chondroitin combination was no better than placebo for pain reduction in OA knee.
While inhibition of Nerve Growth Factor (NGF) afforded excellent pain relief in OA knee, it accelerated the cartilage damage in rat experiments, and seemed to hasten the need for total knee replacement in some patients.
Possibly, the loss of pain and proprioception sensation will aggravate the cartilage damage.
Pain has its reasons.
You win some, you lose some.