Amyloid Crystallopathies: Alzheimer

Alzheimer Disease

Healthy neurons. Image courtesy of NIH. The beta-amyloid fragments begin coming together i

Alzheimer disease (AD) is an acquired disorder of cognitive and behavioral impairment that markedly interferes with social and occupational functioning. It is an incurable disease with a long and…
emedicine.medscape.com

Human amyloid-beta acts as natural antibiotic in the brain: Alzheimer's-associated amyloid plaques may trap microbes

A new study provides additional evidence that amyloid-beta protein -- which is deposited in the form of beta-amyloid plaques in the brains of patients with Alzheimer's disease -- is a normal part of the innate immune system, the body's first-line defense against infection.
sciencedaily.com

Mapping The Brain's Microbiome: Can Studying Germs In The Brain Lead To A Cure For Alzheimer's?

Could it really all come down to infection? Dr. Rudolph E. Tanzi and Robert D. Moir, PhD, of Harvard University and Massachusetts General Hospital, are identifying and studying bacteria, viruses and fungi in the brain in an attempt to cure Alzheimer's.disease.
forbes.com

Alzheimer's Disease and Amyloid: Time to Move On?

2016 ended with the failure of yet another…
Medscape.com


The first-in-human clinical trial targeting Alzheimer's tau protein

For the first time, targeting the other feature of Alzheimer's disease, tau, has given fruitful results. In an unprecedented study, active vaccination in humans has resulted in a favorable immune response in 29 out of the 30 patients with only minor side effects.
sciencedaily.com

Leucomethylthioninium salts (LMTX) by TauRx Therapeutics

TauRx Therapeutics Ltd is a life sciences/pharmaceutical company incorporated in Singapore with primary research facilities and operations in Aberdeen, Scotland.[1][2]
en.wikipedia.org

Anti-TNF Drugs May Protect Against Alzheimer's

ATLANTA -- Treating rheumatoid arthritis patients with anti-tumor necrosis factor (TNF) drugs appears to lessen their likelihood of developing Alzheimer's disease, according to a study reported here.
medpagetoday.com

Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration

Substantial basic science and clinical evidence suggests that excess tumor necrosis factor-alpha (TNF-alpha) is centrally involved in the pathogenesis of Alzheimer's disease. In addition to its pro-inflammatory functions, TNF-alpha has recently been recognized to be a gliotransmitter that regulates…
A ten year study by University of Manchester scientists for a new chemical compound that is able to block a key component in inflammatory illness has ended…
manchester.ac.uk

Given the spectacular and consistent failure of Alzheimer's treatments targeting Tau and Amyloid beta, and emerging evidence that such proteins serve important structural and defence functions (and are therefore epiphenomenal rather than etiological), perhaps the way forward is to target the final common pathway which is the immune response to possible yet-unidentified dysbiotic trigger(s): the NLRP3 inflammasome.

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