Infection and Autoimmunity are like the 2 Sides of The Force: extreme opposites yet inextricably intertwined. Infection can trigger Autoimmunity. Suppressing the latter risks the former running amok. Can Vaccination bring Balance?
The questions are: Who needs what vaccinations? Will they work? Are they safe? When should they be given? No easy answers. The saga, and research, continues.
Patients on Steroids, Methotrexate and Xeljanz may be at higher risk for developing Zoster. Trouble is, the vaccine is "live", contraindicated in patients while on such immunosuppressants.
Opioids are roundly bad in treating rheumatic pain. More evidence in coming days.
Pre-treatment screening and continual pharmacovigilance may have made biologics safer to use.
RA patients on targeted therapies have 50% to 150% higher risk for serious infections, but absolute numbers are low.