Immunology of Cancer

NLRC5/CITA: A Key Player in Cancer Immune Surveillance

Cancer cells need to escape immune surveillance for successful tumor growth. Loss of MHC class I has been described as a major immune evasion strategy in many…
cell.com

Crosstalk between Cytoplasmic RIG-I and STING Sensing Pathways

Detection of evolutionarily conserved molecules on microbial pathogens by host immune sensors represents the initial trigger of the immune response against…
cell.com

Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer

The activation of ER stress pathways endows cancer cells with metastatic and drug-resistance capacities through a number of distinct mechanisms. Targeting these…
cell.com

T cell metabolic fitness in antitumor immunity

T cell metabolism has a central role in supporting and shaping immune responses and may have a key role in antitumor immunity. T cell metabolism is normally held under tight regulation in an immune response of…
cell.com

The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

Myeloid-derived suppressor cells (MDSC) are one of the major components of the tumor microenvironment. The main feature of these cells is their potent immune…
cell.com

Obstacles Posed by the Tumor Microenvironment to T cell Activity: A Case for Synergistic Therapies

T cell dysfunction in solid tumors results from multiple mechanisms. Altered signaling pathways in tumor cells help produce a suppressive tumor microenvironment…
cell.com

Molecular Dissection of CD8+ T-Cell Dysfunction

Chronic viral infections and cancer often lead to the emergence of dysfunctional or ‘exhausted’ CD8+ T cells, and the restoration of their functions is currently the focus of therapeutic interventions. In this review, we detail recent advances in the…
cell.com

Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade

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Anti-CTLA-4 and anti-PD-1 checkpoint-blockade therapies target distinct tumor-infiltrating T cell…
cell.com

TIGIT: A Key Inhibitor of the Cancer Immunity Cycle

Inhibition of the Cancer Immunity Cycle by TIGIT
Immunotherapies that harness the activity of the immune system against
tumors are proving to be an effective therapeutic approach in multiple malignancies. Indeed, through accumulation of…
sciencedirect.com

PSGL-1: A New Player in the Immune Checkpoint Landscape

P-selectin glycoprotein ligand-1 (PSGL-1) has long been studied as an adhesion molecule involved in immune cell trafficking and is recognized as a regulator of…
cell.com

Mechanisms of Immune Tolerance in Leukemia and Lymphoma

Figure 1. Unique and Shared Mechanisms of Immune Evasion in Leukemia and Lymphoma

The mechanisms through which immune responses are generated against solid cancers are well…
sciencedirect.com